Resident memory CD8 T cells trigger protective innate and adaptive immune responses
Science, 2014•science.org
The pathogen recognition theory dictates that, upon viral infection, the innate immune
system first detects microbial products and then responds by providing instructions to
adaptive CD8 T cells. Here, we show in mice that tissue resident memory CD8 T cells (TRM
cells), non-recirculating cells located at common sites of infection, can achieve near-
sterilizing immunity against viral infections by reversing this flow of information. Upon
antigen resensitization within the mouse female reproductive mucosae, CD8+ TRM cells …
system first detects microbial products and then responds by providing instructions to
adaptive CD8 T cells. Here, we show in mice that tissue resident memory CD8 T cells (TRM
cells), non-recirculating cells located at common sites of infection, can achieve near-
sterilizing immunity against viral infections by reversing this flow of information. Upon
antigen resensitization within the mouse female reproductive mucosae, CD8+ TRM cells …
The pathogen recognition theory dictates that, upon viral infection, the innate immune system first detects microbial products and then responds by providing instructions to adaptive CD8 T cells. Here, we show in mice that tissue resident memory CD8 T cells (TRM cells), non-recirculating cells located at common sites of infection, can achieve near-sterilizing immunity against viral infections by reversing this flow of information. Upon antigen resensitization within the mouse female reproductive mucosae, CD8+ TRM cells secrete cytokines that trigger rapid adaptive and innate immune responses, including local humoral responses, maturation of local dendritic cells, and activation of natural killer cells. This provided near-sterilizing immunity against an antigenically unrelated viral infection. Thus, CD8+ TRM cells rapidly trigger an antiviral state by amplifying receptor-derived signals from previously encountered pathogens.
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