[HTML][HTML] Obesity and brain vulnerability in normal and abnormal aging: a multimodal MRI study
Journal of Alzheimer's Disease Reports, 2021•content.iospress.com
Background: How the relationship between obesity and MRI-defined neural properties
varies across distinct stages of cognitive impairment due to Alzheimer's disease is unclear.
Objective: We used multimodal neuroimaging to clarify this relationship. Methods: Scans
were acquired from 47 patients clinically diagnosed with mild Alzheimer's disease dementia,
68 patients with mild cognitive impairment, and 57 cognitively healthy individuals. Voxel-
wise associations were run between maps of gray matter volume, white matter integrity, and …
varies across distinct stages of cognitive impairment due to Alzheimer's disease is unclear.
Objective: We used multimodal neuroimaging to clarify this relationship. Methods: Scans
were acquired from 47 patients clinically diagnosed with mild Alzheimer's disease dementia,
68 patients with mild cognitive impairment, and 57 cognitively healthy individuals. Voxel-
wise associations were run between maps of gray matter volume, white matter integrity, and …
Abstract
Background:
How the relationship between obesity and MRI-defined neural properties varies across distinct stages of cognitive impairment due to Alzheimer’s disease is unclear.
Objective:
We used multimodal neuroimaging to clarify this relationship.
Methods:
Scans were acquired from 47 patients clinically diagnosed with mild Alzheimer’s disease dementia, 68 patients with mild cognitive impairment, and 57 cognitively healthy individuals. Voxel-wise associations were run between maps of gray matter volume, white matter integrity, and cerebral blood flow, and global/visceral obesity.
Results:
Negative associations were found in cognitively healthy individuals between obesity and white matter integrity and cerebral blood flow of temporo-parietal regions. In mild cognitive impairment, negative associations emerged in frontal, temporal, and brainstem regions. In mild dementia, a positive association was found between obesity and gray matter volume around the right temporoparietal junction.
Conclusion:
Obesity might contribute toward neural tissue vulnerability in cognitively healthy individuals and mild cognitive impairment, while a healthy weight in mild Alzheimer’s disease dementia could help preserve brain structure in the presence of age and disease-related weight loss.
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