BDNF in quinolinic acid lesioned rats after bone marrow cells transplant
TS Sánchez, EA Amador, LL Pedre, LB Lezcano… - Neuroscience …, 2014 - Elsevier
TS Sánchez, EA Amador, LL Pedre, LB Lezcano, ID Armesto, JA Bergado
Neuroscience letters, 2014•ElsevierBrain-derived neurotrophic factor (BDNF) concentration was measured in the striatum and
cortex after quinolinic acid intrastriatal lesion and transplantation of bone marrow cells
(BMSC). The results showed a significant increase of the BDNF levels in the striatum and
cortex of the lesioned animals and the ability of the transplanted cells to increase the levels
of BDNF in both sites. This recovery of BDNF production and distribution might have
beneficial effects and ameliorate the negative consequences of the striatal lesion, a …
cortex after quinolinic acid intrastriatal lesion and transplantation of bone marrow cells
(BMSC). The results showed a significant increase of the BDNF levels in the striatum and
cortex of the lesioned animals and the ability of the transplanted cells to increase the levels
of BDNF in both sites. This recovery of BDNF production and distribution might have
beneficial effects and ameliorate the negative consequences of the striatal lesion, a …
Abstract
Brain-derived neurotrophic factor (BDNF) concentration was measured in the striatum and cortex after quinolinic acid intrastriatal lesion and transplantation of bone marrow cells (BMSC). The results showed a significant increase of the BDNF levels in the striatum and cortex of the lesioned animals and the ability of the transplanted cells to increase the levels of BDNF in both sites. This recovery of BDNF production and distribution might have beneficial effects and ameliorate the negative consequences of the striatal lesion, a mechanism of potential interest for the treatment of Huntington's disease (HD).
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