Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen
BB Knowles, CC Howe, DP Aden - Science, 1980 - science.org
BB Knowles, CC Howe, DP Aden
Science, 1980•science.orgAnalysis of the cell culture fluid from two new human hepatoma-derived cell lines reveals
that 17 of the major human plasma proteins are synthesized and secreted by these cells.
One of these cell lines, Hep 3B, also produces the two major polypeptides of the hepatitis B
virus surface antigen. When Hep 3B is injected into athymic mice, metastatic hepatocellular
carcinomas appear. These cell lines provide experimental models for investigation of
plasma protein biosynthesis and the relation of the hepatitis B virus genome to …
that 17 of the major human plasma proteins are synthesized and secreted by these cells.
One of these cell lines, Hep 3B, also produces the two major polypeptides of the hepatitis B
virus surface antigen. When Hep 3B is injected into athymic mice, metastatic hepatocellular
carcinomas appear. These cell lines provide experimental models for investigation of
plasma protein biosynthesis and the relation of the hepatitis B virus genome to …
Analysis of the cell culture fluid from two new human hepatoma-derived cell lines reveals that 17 of the major human plasma proteins are synthesized and secreted by these cells. One of these cell lines, Hep 3B, also produces the two major polypeptides of the hepatitis B virus surface antigen. When Hep 3B is injected into athymic mice, metastatic hepatocellular carcinomas appear. These cell lines provide experimental models for investigation of plasma protein biosynthesis and the relation of the hepatitis B virus genome to tumorigenicity.
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