Can podocytes be regenerated in adults?
SJ Shankland, BS Freedman… - Current opinion in …, 2017 - journals.lww.com
SJ Shankland, BS Freedman, JW Pippin
Current opinion in nephrology and hypertension, 2017•journals.lww.comRecent studies indicate that the podocyte compartment is more dynamic than previously
believed. Bidirectional exchange with neighboring cellular compartments provides a
mechanism for podocyte replacement. Based on these findings, we propose a set of criteria
for evaluating podocyte regeneration and suggest that restoration of podocyte number to a
subsclerotic threshold be targeted as a potentially achievable clinical goal.
believed. Bidirectional exchange with neighboring cellular compartments provides a
mechanism for podocyte replacement. Based on these findings, we propose a set of criteria
for evaluating podocyte regeneration and suggest that restoration of podocyte number to a
subsclerotic threshold be targeted as a potentially achievable clinical goal.
Summary
Recent studies indicate that the podocyte compartment is more dynamic than previously believed. Bidirectional exchange with neighboring cellular compartments provides a mechanism for podocyte replacement. Based on these findings, we propose a set of criteria for evaluating podocyte regeneration and suggest that restoration of podocyte number to a subsclerotic threshold be targeted as a potentially achievable clinical goal.
Lippincott Williams & Wilkins