ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma
M Miettinen, ZF Wang, A Paetau, SH Tan… - The American journal …, 2011 - journals.lww.com
ERG, an ETS family transcription factor, is known to be expressed in endothelial cells, and
oncogenic ERG gene fusions occur in subsets of prostatic carcinoma, acute myeloid
leukemia, and Ewing sarcoma. In this study, we immunohistochemically investigated nuclear
ERG expression using a new monoclonal antibody, CPDR ERG-MAb, that is highly specific
for detecting ERG protein and ERG-expressing prostate carcinomas. A broad range of
vascular endothelial (n= 250), other mesenchymal (n= 973), and epithelial tumors (n= 657) …
oncogenic ERG gene fusions occur in subsets of prostatic carcinoma, acute myeloid
leukemia, and Ewing sarcoma. In this study, we immunohistochemically investigated nuclear
ERG expression using a new monoclonal antibody, CPDR ERG-MAb, that is highly specific
for detecting ERG protein and ERG-expressing prostate carcinomas. A broad range of
vascular endothelial (n= 250), other mesenchymal (n= 973), and epithelial tumors (n= 657) …