The biologic price of aging includes progressive deterioration of renal function and structure.
After the age of 30, glomerular filtration and renal blood flow rates decline in a linear fashion,
so that values in octagenarians are only half to two thirds those measured in young adults.
Renal mass similarly declines, and the incidence of sclerotic glomeruli increases with
advancing age. Accordingly, the aging kidney is at high risk of eventual failure when
functioning nephron number is further reduced by acquired renal disease. Recent evidence …