AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-β1 promoter in mesangial cells
C Weigert, U Sauer, K Brodbeck, A Pfeiffer… - Journal of the …, 2000 - journals.lww.com
Hyperglycemia-induced overproduction of the prosclerotic cytokine transforming growth
factor-β1 (TGF-β1) has been implicated in the pathogenesis of diabetic nephropathy.
Because high glucose and phorbol esters (PMA) increase TGF-β1 mRNA levels in
mesangial cells, this study was designed to characterize these effects on the human TGF-β1
promoter activity. With the use of luciferase reporter gene constructs containing TGF-β1 5′-
flanking sequence (from-453 to+ 11 bp) transfected into mesangial cells, it was found that 30 …
factor-β1 (TGF-β1) has been implicated in the pathogenesis of diabetic nephropathy.
Because high glucose and phorbol esters (PMA) increase TGF-β1 mRNA levels in
mesangial cells, this study was designed to characterize these effects on the human TGF-β1
promoter activity. With the use of luciferase reporter gene constructs containing TGF-β1 5′-
flanking sequence (from-453 to+ 11 bp) transfected into mesangial cells, it was found that 30 …