Background Besides chronic stress, chronic pain is a prevalent determinant for depression.
Changes induced in specific brain regions by sustained pain may alter the processing of
affective information, thus resulting in anxiodepressive disorders. Here, we compared the
role of the anterior cingulate cortex (ACC) and the posterior insular cortex in the
anxiodepressive, sensory, and affective aspects of chronic pain. Methods Neuropathic pain
was induced by cuffing the right sciatic nerve of C57BL/6J mice. Lesions were performed by …