Integrin αβ transmembrane heterodimers play central roles in metazoan development and
physiology by mediating adhesion and by transmitting forces and biochemical signals
across the plasma membrane. In this SnapShot, we present a simplified" modular" view of
the integrin adhesome, centered on the talin-integrin interaction, and provide examples of
how this view can help to unravel the adhesome's remarkable functional diversity and
plasticity.