Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA–mDia2 signaling and filopodium formation
E Argenzio, J Klarenbeek, KM Kedziora… - Journal of Biological …, 2018 - ASBMB
Chloride intracellular channel 4 (CLIC4) is a cytosolic protein implicated in diverse actin-
based processes, including integrin trafficking, cell adhesion, and tubulogenesis. CLIC4 is
rapidly recruited to the plasma membrane by RhoA-activating agonists and then partly
colocalizes with β1 integrins. Agonist-induced CLIC4 translocation depends on actin
polymerization and requires conserved residues that make up a putative binding groove.
However, the mechanism and significance of CLIC4 trafficking have been elusive. Here, we …
based processes, including integrin trafficking, cell adhesion, and tubulogenesis. CLIC4 is
rapidly recruited to the plasma membrane by RhoA-activating agonists and then partly
colocalizes with β1 integrins. Agonist-induced CLIC4 translocation depends on actin
polymerization and requires conserved residues that make up a putative binding groove.
However, the mechanism and significance of CLIC4 trafficking have been elusive. Here, we …
