Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study
LL Altshuler, SY Bookheimer, J Townsend… - Biological …, 2005 - Elsevier
BACKGROUND: Patients with bipolar disorder have been reported to have abnormal
cortical function during mania. In this study, we sought to investigate neural activity in the
frontal lobe during mania, using functional magnetic resonance imaging (fMRI). Specifically,
we sought to evaluate activation in the lateral orbitofrontal cortex, a brain region that is
normally activated during activities that require response inhibition. METHODS: Eleven
manic subjects and 13 control subjects underwent fMRI while performing the Go-NoGo task …
cortical function during mania. In this study, we sought to investigate neural activity in the
frontal lobe during mania, using functional magnetic resonance imaging (fMRI). Specifically,
we sought to evaluate activation in the lateral orbitofrontal cortex, a brain region that is
normally activated during activities that require response inhibition. METHODS: Eleven
manic subjects and 13 control subjects underwent fMRI while performing the Go-NoGo task …
