Compartmentation of the cerebellar cortex by protein kinase C delta
S Chen, DE Hillman - Neuroscience, 1993 - Elsevier
S Chen, DE Hillman
Neuroscience, 1993•ElsevierSix isozymes of protein kinase C were analysed in the rat cerebellum using
immunohistochemistry. The results revealed a non-uniform distribution of protein kinase C
delta among Purkinje, basket, and stellate cells. Serial-section mapping of the delta
immunoreactivity revealed that (i) the number and intensity of labeled Purkinje cells
increased from rostral to caudal while labeled basket-stellate cells decreased caudally;(ii)
the majority of Purkinje cells were labeled in the nodulus, flocculus, and paraflocculus while …
immunohistochemistry. The results revealed a non-uniform distribution of protein kinase C
delta among Purkinje, basket, and stellate cells. Serial-section mapping of the delta
immunoreactivity revealed that (i) the number and intensity of labeled Purkinje cells
increased from rostral to caudal while labeled basket-stellate cells decreased caudally;(ii)
the majority of Purkinje cells were labeled in the nodulus, flocculus, and paraflocculus while …
Abstract
Six isozymes of protein kinase C were analysed in the rat cerebellum using immunohistochemistry. The results revealed a non-uniform distribution of protein kinase C delta among Purkinje, basket, and stellate cells. Serial-section mapping of the delta immunoreactivity revealed that
- (i)the number and intensity of labeled Purkinje cells increased from rostral to caudal while labeled basket-stellate cells decreased caudally;
- (ii)the majority of Purkinje cells were labeled in the nodulus, flocculus, and paraflocculus while the anterior lobules were mostly negative; and
- (iii)labeled Purkinje cells formed distinct parasagittal bands in lobules 6–9 of the paravermis and vermis.
The banding of protein kinase C delta within subsets of Purkinje cells suggests units of cerebellar circuitry with specific signaling properties through protein phosphorylation. The visual-vestibular regions of the cerebellum contained the highest amount of the isozyme.
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