Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and zucker diabetic fatty rats and effects of rosiglitazone
XJ Cai, CA Lister, RE Buckingham, L Pickavance… - Molecular brain …, 2000 - Elsevier
Orexins (hypocretins) are lateral hypothalamic neuropeptides implicated in regulating
feeding and the sleep–wake cycle. To study their possible relevance to obesity and
diabetes, we measured hypothalamic prepro-orexin mRNA levels in obese, normoglycemic
Zucker fatty (fa/fa) and in hyperglycemic, non-obese Zucker diabetic fatty (ZDF) rats.
Hypothalamic prepro-orexin mRNA concentrations in Zucker fatty rats were 31% lower than
those in lean controls (0.69±0.06 vs. 1.00±0.10 arbitrary units, P< 0.05), but did not differ …
feeding and the sleep–wake cycle. To study their possible relevance to obesity and
diabetes, we measured hypothalamic prepro-orexin mRNA levels in obese, normoglycemic
Zucker fatty (fa/fa) and in hyperglycemic, non-obese Zucker diabetic fatty (ZDF) rats.
Hypothalamic prepro-orexin mRNA concentrations in Zucker fatty rats were 31% lower than
those in lean controls (0.69±0.06 vs. 1.00±0.10 arbitrary units, P< 0.05), but did not differ …
