Intrathecal delivery of viral vectors for gene therapy
A Kagiava, KA Kleopa - Myelin: Methods and Protocols, 2018 - Springer
A Kagiava, KA Kleopa
Myelin: Methods and Protocols, 2018•SpringerGene delivery to the peripheral nervous system for therapeutic applications remains
technically challenging but could eventually have a significant impact on the development of
innovative treatments not only for inherited but also for acquired peripheral neuropathies.
Here we describe the method for lumbar intrathecal injection of viral vectors in experimental
mice. This gene delivery route provides widespread and stable over time Schwann cell-
targeted or ubiquitous gene expression in the peripheral nervous system.
technically challenging but could eventually have a significant impact on the development of
innovative treatments not only for inherited but also for acquired peripheral neuropathies.
Here we describe the method for lumbar intrathecal injection of viral vectors in experimental
mice. This gene delivery route provides widespread and stable over time Schwann cell-
targeted or ubiquitous gene expression in the peripheral nervous system.
Abstract
Gene delivery to the peripheral nervous system for therapeutic applications remains technically challenging but could eventually have a significant impact on the development of innovative treatments not only for inherited but also for acquired peripheral neuropathies. Here we describe the method for lumbar intrathecal injection of viral vectors in experimental mice. This gene delivery route provides widespread and stable over time Schwann cell-targeted or ubiquitous gene expression in the peripheral nervous system.
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