Deposition of fibrillar amyloid-β protein (Aβ) in senile plaques and in the walls of cerebral
blood vessels is a key pathological feature of Alzheimer's disease and certain related
disorders. Fibrillar Aβ deposition is intimately associated with neuronal and cerebrovascular
cell death both in vivo and in vitro. Similarly, accumulation of the Aβ protein precursor
(AβPP) is also observed at sites of fibrillar Aβ deposition. Recently, we reported that fibrillar
Aβ, but not unassembled Aβ, promotes the specific binding of AβPP through its cysteine-rich …