[HTML][HTML] Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
JW Wu, M Herman, L Liu, S Simoes, CM Acker… - Journal of Biological …, 2013 - ASBMB
The accumulation of Tau into aggregates is associated with key pathological events in
frontotemporal lobe degeneration (FTD-Tau) and Alzheimer disease (AD). Recent data have
shown that misfolded Tau can be internalized by cells in vitro (Frost, B., Jacks, RL, and
Diamond, MI (2009) J. Biol. Chem. 284, 12845–12852) and propagate pathology in vivo
(Clavaguera, F., Bolmont, T., Crowther, RA, Abramowski, D., Frank, S., Probst, A., Fraser, G.,
Stalder, AK, Beibel, M., Staufenbiel, M., Jucker, M., Goedert, M., and Tolnay, M.(2009) Nat …
frontotemporal lobe degeneration (FTD-Tau) and Alzheimer disease (AD). Recent data have
shown that misfolded Tau can be internalized by cells in vitro (Frost, B., Jacks, RL, and
Diamond, MI (2009) J. Biol. Chem. 284, 12845–12852) and propagate pathology in vivo
(Clavaguera, F., Bolmont, T., Crowther, RA, Abramowski, D., Frank, S., Probst, A., Fraser, G.,
Stalder, AK, Beibel, M., Staufenbiel, M., Jucker, M., Goedert, M., and Tolnay, M.(2009) Nat …
