Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line
L Alvarez-Erviti, Y Couch, J Richardson… - Neuroscience …, 2011 - Elsevier
The neurodegenerative process in Parkinson's disease (PD) is accompanied by the
presence of a neuroinflammatory response, which has been suggested as one of the
principal components involved in PD progression. In this report we assessed the
inflammatory potential of alpha-synuclein, a protein central to PD pathogenesis, released by
neurons on the mouse microglia cell line BV-2. BV-2 cells were treated with conditioned
medium isolated from normal SH-SY5Y cells and clones that over-express WT or mutant …
presence of a neuroinflammatory response, which has been suggested as one of the
principal components involved in PD progression. In this report we assessed the
inflammatory potential of alpha-synuclein, a protein central to PD pathogenesis, released by
neurons on the mouse microglia cell line BV-2. BV-2 cells were treated with conditioned
medium isolated from normal SH-SY5Y cells and clones that over-express WT or mutant …
