Toward an improved definition of acute-on-chronic liver failure
Acute clinical deterioration in patients with chronic liver disease may result in multisystem
organ failure and is associated with significant morbidity and mortality, with per-patient costs
associated with intensive care ranging between $116,000 and $180,000 in the United
States. 1 Mortality in these patients, however, has remained unchanged over the past 20
years at> 50%. As a means of identifying patients with cirrhosis at high risk for acute
deterioration, both the Asia-Pacific Association for the Study of the Liver (APASL) and a joint …
organ failure and is associated with significant morbidity and mortality, with per-patient costs
associated with intensive care ranging between $116,000 and $180,000 in the United
States. 1 Mortality in these patients, however, has remained unchanged over the past 20
years at> 50%. As a means of identifying patients with cirrhosis at high risk for acute
deterioration, both the Asia-Pacific Association for the Study of the Liver (APASL) and a joint …
