Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D
EN Atochina, JM Beck, ST Scanlon, AM Preston… - Journal of Laboratory …, 2001 - Elsevier
Surfactant proteins SP-A and SP-D, members of the collectin family, have been shown to
play a significant role in lung host defense. Both proteins selectively bind Pneumocystis
carinii (PC) organisms and modulate the interaction of this pathogen with alveolar
macrophages. We hypothesized that the expression and distribution of lung collectins SP-A
and SP-D is altered by PC lung infection. PC organisms (2× 105) were inoculated
intratracheally into CB–17 scid/scid mice that do not require steroids for …
play a significant role in lung host defense. Both proteins selectively bind Pneumocystis
carinii (PC) organisms and modulate the interaction of this pathogen with alveolar
macrophages. We hypothesized that the expression and distribution of lung collectins SP-A
and SP-D is altered by PC lung infection. PC organisms (2× 105) were inoculated
intratracheally into CB–17 scid/scid mice that do not require steroids for …
