[HTML][HTML] Dual 12/15-and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock …
Lipoxygenase (LO) enzymes catalyze the conversion of arachidonic acid (AA) into
biologically active lipid mediators. Two members, 12/15-LO and 5-LO, regulate inflammatory
responses and have been studied for their roles in atherogenesis. Both 12/15-LO and 5-LO
inhibitors have been suggested as potential therapy to limit the development of
atherosclerotic lesions. Here we used a genetic strategy to disrupt both 12/15-LO and 5-LO
on an apolipoprotein E (apoE) atherosclerosis-susceptible background to study the impact …
biologically active lipid mediators. Two members, 12/15-LO and 5-LO, regulate inflammatory
responses and have been studied for their roles in atherogenesis. Both 12/15-LO and 5-LO
inhibitors have been suggested as potential therapy to limit the development of
atherosclerotic lesions. Here we used a genetic strategy to disrupt both 12/15-LO and 5-LO
on an apolipoprotein E (apoE) atherosclerosis-susceptible background to study the impact …