A causal role for the human tumor antigen preferentially expressed antigen of melanoma in cancer

MT Epping, R Bernards - Cancer research, 2006 - AACR
MT Epping, R Bernards
Cancer research, 2006AACR
Tumor antigens are of interest as diagnostic and prognostic markers and potential
therapeutic targets. The tumor antigen preferentially expressed antigen of melanoma
(PRAME) is frequently overexpressed in a wide variety of cancers and is a prognostic
marker for clinical outcome. It has been shown recently that PRAME functions as a repressor
of retinoic acid signaling. Here, we discuss this novel insight in the context of the increasing
interest in tumor antigens as targets for therapy.(Cancer Res 2006; 66 (22): 10639-42)
Abstract
Tumor antigens are of interest as diagnostic and prognostic markers and potential therapeutic targets. The tumor antigen preferentially expressed antigen of melanoma (PRAME) is frequently overexpressed in a wide variety of cancers and is a prognostic marker for clinical outcome. It has been shown recently that PRAME functions as a repressor of retinoic acid signaling. Here, we discuss this novel insight in the context of the increasing interest in tumor antigens as targets for therapy. (Cancer Res 2006; 66(22): 10639-42)
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