[HTML][HTML] Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

F Wadelin, J Fulton, PA McEwan, KA Spriggs, J Emsley… - Molecular cancer, 2010 - Springer
F Wadelin, J Fulton, PA McEwan, KA Spriggs, J Emsley, DM Heery
Molecular cancer, 2010Springer
Abstract PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at
high levels in haematological malignancies and solid tumours. The physiological functions
of PRAME in normal and tumour cells are unknown, although a role in the regulation of
retinoic acid signalling has been proposed. Sequence homology and structural predictions
suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which
have diverse functions. Here we review the current knowledge of the structure/function of …
Abstract
PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.
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