DR negativity is a distinctive feature of M1/M2 AML cases with NPM1 mutation

M Syampurnawati, E Tatsumi, B Ardianto… - Leukemia research, 2008 - Elsevier
Our previous observation of a higher incidence of FLT3-ITD in DR− M1/M2 AML than in DR+
M1/M2 led to an investigation of NPM1 mutation in the same samples, since DR− AML and
AML with NPM1 mutation share such characteristics as normal karyotype, the absence of
CD34, and FLT3-ITD. NPM1 mutation was found in 18 of 26 (69.2%) of DR− cases, but not in
any of 28 DR+ cases. FLT3-ITD was noted in 66.7% of the cases with NPM1 mutation. These
findings point to DR negativity as another phenotypic feature of AML with NPM1 mutation.