Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

M Henkemeyer, DJ Rossi, DP Holmyard, MC Puri… - Nature, 1995 - nature.com
M Henkemeyer, DJ Rossi, DP Holmyard, MC Puri, G Mbamalu, K Harpal, TS Shih, T Jacks
Nature, 1995nature.com
The gene encoding p120-rasGAP, a negative regulator of Ras, has been disrupted in mice.
This Gap mutation affects the ability of endothelial cells to organize into a highly
vascularized network and results in extensive neuronal cell death. Mutations in the Gap and
Nfl genes have a synergistic effect, such that embryos homozygous for mutations in both
genes show an exacerbated Gap phenotype. Thus rasGAP and neurofibromin act together
to regulate Ras activity during embryonic development.
Abstract
The gene encoding p120-rasGAP, a negative regulator of Ras, has been disrupted in mice. This Gap mutation affects the ability of endothelial cells to organize into a highly vascularized network and results in extensive neuronal cell death. Mutations in the Gap and Nfl genes have a synergistic effect, such that embryos homozygous for mutations in both genes show an exacerbated Gap phenotype. Thus rasGAP and neurofibromin act together to regulate Ras activity during embryonic development.
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