Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia

N Carrera, M Arrojo, J Sanjuán, R Ramos-Ríos… - Biological …, 2012 - Elsevier
BACKGROUND: Genome-wide association studies using several hundred thousand
anonymous markers present limited statistical power. Alternatively, association studies
restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the
advantage of strongly reducing the multiple testing problem, while increasing the probability
of testing functional single nucleotide polymorphisms (SNPs). METHODS: We performed a
case-control association study of common nsSNPs in Galician (northwest Spain) samples …