The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

BK Yoder, X Hou… - Journal of the American …, 2002 - journals.lww.com
Recent evidence has suggested an association between structural and/or functional defects
in the primary apical cilium of vertebrate epithelia and polycystic kidney disease (PKD). In
Caenorhabditis elegans, the protein orthologues of the PKD-related proteins, polycystin-1
(LOV-1), polycystin-2 (PKD2), and polaris (OSM-5), co-localize in the cilia of male-specific
sensory neurons, and defects in these proteins cause abnormalities of cilia structure and/or
function. This study sought to determine whether the mammalian polycystins are expressed …