[HTML][HTML] Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking

ML Allende, M Bektas, BG Lee, E Bonifacino… - Journal of Biological …, 2011 - ASBMB
Sphingosine-1-phosphate (S1P) lyase catalyzes the degradation of S1P, a potent signaling
lysosphingolipid. Mice with an inactive S1P lyase gene are impaired in the capacity to
degrade S1P, resulting in highly elevated S1P levels. These S1P lyase-deficient mice have
low numbers of lymphocytes and high numbers of neutrophils in their blood. We found that
the S1P lyase-deficient mice exhibited features of an inflammatory response including
elevated levels of pro-inflammatory cytokines and an increased expression of genes in liver …