[HTML][HTML] Complement cascade gene expression defines novel prognostic subgroups of acute myeloid leukemia
I Laverdière, M Boileau, T Herold, J Rak… - Experimental …, 2016 - Elsevier
Highlights•Complement pathway gene expression is variable across acute myeloid
leukemia samples.•Complement regulator genes are implicated in poor outcome in patients
with acute myeloid leukemia.•A three-gene signature of CFH, CFD, and SERPING1 is a
highly prognostic marker.The involvement of the complement pathway in cancer is
supported by a growing body of evidence, and yet its role in acute myeloid leukemia (AML)
has not been extensively studied. We examined the expression of 87 genes in the …
leukemia samples.•Complement regulator genes are implicated in poor outcome in patients
with acute myeloid leukemia.•A three-gene signature of CFH, CFD, and SERPING1 is a
highly prognostic marker.The involvement of the complement pathway in cancer is
supported by a growing body of evidence, and yet its role in acute myeloid leukemia (AML)
has not been extensively studied. We examined the expression of 87 genes in the …