[HTML][HTML] The next opportunity in anti-malaria drug discovery: the liver stage
PLoS pathogens, 2011•journals.plos.org
Background Humans have suffered from the burden of malarial infections for thousands of
years, and the disease has greatly influenced human evolution and history [1]–[3]. Malaria
remains a devastating disease, and in developing countries within Africa, South America,
and Asia, the size of its burden has stifled economic growth and development [2]. Despite
successful eradication campaigns in North America and Europe, global cases of the disease
show little decline, and current improvements rely on pyrethroid treated bed nets and …
years, and the disease has greatly influenced human evolution and history [1]–[3]. Malaria
remains a devastating disease, and in developing countries within Africa, South America,
and Asia, the size of its burden has stifled economic growth and development [2]. Despite
successful eradication campaigns in North America and Europe, global cases of the disease
show little decline, and current improvements rely on pyrethroid treated bed nets and …
Background
Humans have suffered from the burden of malarial infections for thousands of years, and the disease has greatly influenced human evolution and history [1]–[3]. Malaria remains a devastating disease, and in developing countries within Africa, South America, and Asia, the size of its burden has stifled economic growth and development [2]. Despite successful eradication campaigns in North America and Europe, global cases of the disease show little decline, and current improvements rely on pyrethroid treated bed nets and combination therapeutics containing artemisinin derivatives, both of which are susceptible to emerging resistance [4]. Our ability to counter these vulnerabilities with new agents is hampered by the modest number of fully validated drug targets and our limited understanding of many aspects of parasite biology.
PLOS