[HTML][HTML] Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2
M Valapala, JK Vishwanatha - Journal of Biological Chemistry, 2011 - ASBMB
Annexin A2 (AnxA2), a Ca 2+-dependent phospholipid-binding protein, is known to
associate with the plasma membrane and the endosomal system. Within the plasma
membrane, AnxA2 associates in a Ca 2+ dependent manner with cholesterol-rich lipid raft
microdomains. Here, we show that the association of AnxA2 with the lipid rafts is influenced
not only by intracellular levels of Ca 2+ but also by N-terminal phosphorylation at tyrosine
23. Binding of AnxA2 to the lipid rafts is followed by the transport along the endocytic …
associate with the plasma membrane and the endosomal system. Within the plasma
membrane, AnxA2 associates in a Ca 2+ dependent manner with cholesterol-rich lipid raft
microdomains. Here, we show that the association of AnxA2 with the lipid rafts is influenced
not only by intracellular levels of Ca 2+ but also by N-terminal phosphorylation at tyrosine
23. Binding of AnxA2 to the lipid rafts is followed by the transport along the endocytic …