Importance Coronary artery calcium (CAC), measured by computed tomography (CT), has
strong predictive value for incident cardiovascular disease (CVD) events. The standard CAC
score is the Agatston, which is weighted upward for greater calcium density. However, some
data suggest increased plaque calcium density may be protective for CVD. Objective To
determine the independent associations of CAC volume and CAC density with incident CVD
events. Design, Setting, and Participants Multicenter, prospective observational MESA study …