Tumor-released microvesicles as vehicles of immunosuppression
R Valenti, V Huber, M Iero, P Filipazzi, G Parmiani… - Cancer research, 2007 - AACR
R Valenti, V Huber, M Iero, P Filipazzi, G Parmiani, L Rivoltini
Cancer research, 2007•AACRTumor-released microvesicles, or exosomes, which are abundant in the body fluids of
patients with cancer, are likely to be involved in tumor progression. We recently showed that
microvesicles released by human melanoma and colorectal carcinoma cells can promote
the differentiation of monocytes to myeloid-derived suppressor cells which support tumoral
growth and immune escape. These findings underscore an important role for these
extracellular organelles in remodeling tumor-stromal interactions to promote …
patients with cancer, are likely to be involved in tumor progression. We recently showed that
microvesicles released by human melanoma and colorectal carcinoma cells can promote
the differentiation of monocytes to myeloid-derived suppressor cells which support tumoral
growth and immune escape. These findings underscore an important role for these
extracellular organelles in remodeling tumor-stromal interactions to promote …
Abstract
Tumor-released microvesicles, or exosomes, which are abundant in the body fluids of patients with cancer, are likely to be involved in tumor progression. We recently showed that microvesicles released by human melanoma and colorectal carcinoma cells can promote the differentiation of monocytes to myeloid-derived suppressor cells which support tumoral growth and immune escape. These findings underscore an important role for these extracellular organelles in remodeling tumor-stromal interactions to promote malignancy. [Cancer Res 2007;67(7):2912–5]
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