[HTML][HTML] Flow-regulated lymphatic vasculature development and signaling
Y Wang, M Simons - Vascular Cell, 2014 - Springer
Y Wang, M Simons
Vascular Cell, 2014•SpringerThe role of blood flow in regulating signaling pathways and gene expression in the blood
vasculature is well known. Recent studies have identified equally important roles of flow-
mediated signaling in the lymphatic circulation including control of lymphatic vascular
growth, remodeling, regeneration and maintenance of the lymphatic fate. In this review, we
summarize these advances focusing on the role of fluid dynamics in control of lymphatic
vasculature formation.
vasculature is well known. Recent studies have identified equally important roles of flow-
mediated signaling in the lymphatic circulation including control of lymphatic vascular
growth, remodeling, regeneration and maintenance of the lymphatic fate. In this review, we
summarize these advances focusing on the role of fluid dynamics in control of lymphatic
vasculature formation.
Abstract
The role of blood flow in regulating signaling pathways and gene expression in the blood vasculature is well known. Recent studies have identified equally important roles of flow-mediated signaling in the lymphatic circulation including control of lymphatic vascular growth, remodeling, regeneration and maintenance of the lymphatic fate. In this review, we summarize these advances focusing on the role of fluid dynamics in control of lymphatic vasculature formation.
Springer