The regulation of IL-13ralpha1 and IL-13ralpha2 expression and distribution in airway epithelial repair
JSY Yang, SJ Wadsworth, GK Singhera… - B34. Epithelial Cell …, 2011 - atsjournals.org
JSY Yang, SJ Wadsworth, GK Singhera, D Dorscheid
B34. Epithelial Cell Activity, 2011•atsjournals.orgObjective: Although IL-13 is known to be a key cytokine in mediating inflammatory and
remodelling responses, our lab has shown that IL-13 is critical to airway epithelial repair via
the release of HB-EGF and activation of EGF-R. The effects of IL-13 are mediated through
two receptors, IL-13 receptor α1 (IL-13Rα1)/IL-4 receptor (IL-4Rα) and IL-13 receptor α2 (IL-
13Rα2). In the current investigation we studied the roles of these receptors in normal airway
epithelial repair, particularly focusing on their expression, distribution and interaction in …
remodelling responses, our lab has shown that IL-13 is critical to airway epithelial repair via
the release of HB-EGF and activation of EGF-R. The effects of IL-13 are mediated through
two receptors, IL-13 receptor α1 (IL-13Rα1)/IL-4 receptor (IL-4Rα) and IL-13 receptor α2 (IL-
13Rα2). In the current investigation we studied the roles of these receptors in normal airway
epithelial repair, particularly focusing on their expression, distribution and interaction in …
Objective:
Although IL-13 is known to be a key cytokine in mediating inflammatory and remodelling responses, our lab has shown that IL-13 is critical to airway epithelial repair via the release of HB-EGF and activation of EGF-R. The effects of IL-13 are mediated through two receptors, IL-13 receptor α1 (IL-13Rα1)/IL-4 receptor (IL-4Rα) and IL-13 receptor α2 (IL-13Rα2). In the current investigation we studied the roles of these receptors in normal airway epithelial repair, particularly focusing on their expression, distribution and interaction in response to injury signals.
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