Studies of mice with genetic deficits in specific coagulation factors have shown that many,
but not all, components of the hemostatic system serve an essential role in mouse
embryogenesis and pregnancy. Although the developmental failures observed in these mice
are typically associated with severe hemorrhage, it is uncertain whether the role of
coagulation factors in embryogenesis and reproduction is specifically tied to their function in
thrombus formation and prevention of blood loss (ie hemostasis). Here, we show (i) that a …