[HTML][HTML] P2X7 regulation of macrophage tissue factor activity and microparticle generation
R Lee, JC Williams, N Mackman - Journal of Thrombosis and …, 2012 - jthjournal.org
Tissue factor (TF) is the high-affinity receptor for factor (F) VII/VIIa [1]. It is expressed by cells
surrounding blood vessels and in certain tissues and is required for hemostasis [2]. During
Gram-negative bacterial infection, lipopolysaccharide (LPS) induces TF expression in
circulating monocytes [3–5] resulting in local clot formation to immobilize the bacterium and
limit the spread of the infection. LPS induction of TF gene expression in human monocytic
cells has been studied in detail and requires the activation and nuclear translocation of …
surrounding blood vessels and in certain tissues and is required for hemostasis [2]. During
Gram-negative bacterial infection, lipopolysaccharide (LPS) induces TF expression in
circulating monocytes [3–5] resulting in local clot formation to immobilize the bacterium and
limit the spread of the infection. LPS induction of TF gene expression in human monocytic
cells has been studied in detail and requires the activation and nuclear translocation of …