Transglutaminase 2 exacerbates experimental autoimmune encephalomyelitis through positive regulation of encephalitogenic T cell differentiation and inflammation
K Oh, HB Park, MW Seo, OJ Byoun, DS Lee - Clinical immunology, 2012 - Elsevier
The increased activity of transglutaminase 2 (TG2) in various inflammatory and fibrotic
conditions results in the development of numerous disease processes. Experimental
autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is an
inflammatory and demyelinating disease of the central nervous system and is mediated by
many inflammatory cytokines and mediators. We examined the role of TG2 in
encephalitogenic CD4+ T cell responses and EAE development using mice lacking TG2 …
conditions results in the development of numerous disease processes. Experimental
autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, is an
inflammatory and demyelinating disease of the central nervous system and is mediated by
many inflammatory cytokines and mediators. We examined the role of TG2 in
encephalitogenic CD4+ T cell responses and EAE development using mice lacking TG2 …