[HTML][HTML] Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2
C Ogawa, A Kihara, M Gokoh, Y Igarashi - Journal of Biological Chemistry, 2003 - ASBMB
Sphingosine 1-phosphate (S1P) is a bioactive lipid molecule that acts as both an
extracellular signaling mediator and an intracellular second messenger. S1P is synthesized
from sphingosine by sphingosine kinase and is degraded either by S1P lyase or by S1P
phosphohydrolase. Recently, mammalian S1P phosphohydrolase (SPP1) was identified
and shown to constitute a novel lipid phosphohydrolase family, the SPP family. In this study
we have identified a second human S1P phosphohydrolase, SPP2, based on sequence …
extracellular signaling mediator and an intracellular second messenger. S1P is synthesized
from sphingosine by sphingosine kinase and is degraded either by S1P lyase or by S1P
phosphohydrolase. Recently, mammalian S1P phosphohydrolase (SPP1) was identified
and shown to constitute a novel lipid phosphohydrolase family, the SPP family. In this study
we have identified a second human S1P phosphohydrolase, SPP2, based on sequence …