Histogenesis of cholangiomas and cholangiocarcinomas in thioacetamide fed rats
MM Praet, HJ Roels - Experimental pathology, 1984 - Elsevier
A sequential, histologic analysis of the livers of male albino rats chronically fed the
hepatocarcinogen thioacetamide (TJAA) is performed after one, two, three, four, eight and
twelve months of treatment. Liver cell alterations present after one, two and three months
consist of centrolobular liver cell degeneration and oval cell proliferation. After 8 months of
TAA treatment, a variety of benign tumors (cystadenomas, angiomas, cholangiomas) is
observed. From the 12th month all experimental animals develop cholangiocarcinomas …
hepatocarcinogen thioacetamide (TJAA) is performed after one, two, three, four, eight and
twelve months of treatment. Liver cell alterations present after one, two and three months
consist of centrolobular liver cell degeneration and oval cell proliferation. After 8 months of
TAA treatment, a variety of benign tumors (cystadenomas, angiomas, cholangiomas) is
observed. From the 12th month all experimental animals develop cholangiocarcinomas …