Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock
J Sundén-Cullberg, A Norrby-Teglund… - Critical care …, 2005 - journals.lww.com
Objective: To study the systemic release and kinetics of high mobility group box-1 protein
(HMGB1) in relation to clinical features in a population of patients with severe sepsis or
septic shock and to compare these with the kinetics of the cytokines interleukin-6, interleukin-
8, interleukin-10, and tumor necrosis factor-α. Design: Prospective study of two cohorts of
patients. Setting: Intensive care unit and infectious disease clinic at Karolinska University
Hospital Huddinge. Patients: Twenty-six patients with severe sepsis, 33 patients with septic …
(HMGB1) in relation to clinical features in a population of patients with severe sepsis or
septic shock and to compare these with the kinetics of the cytokines interleukin-6, interleukin-
8, interleukin-10, and tumor necrosis factor-α. Design: Prospective study of two cohorts of
patients. Setting: Intensive care unit and infectious disease clinic at Karolinska University
Hospital Huddinge. Patients: Twenty-six patients with severe sepsis, 33 patients with septic …