[HTML][HTML] Nuclear calpain regulates Ca2+-dependent signaling via proteolysis of nuclear Ca2+/calmodulin-dependent protein kinase type IV in cultured neurons
B Tremper-Wells, ML Vallano - Journal of Biological Chemistry, 2005 - ASBMB
Accumulating evidence indicates that calpains can reside in or translocate to the cell
nucleus, but their functions in this compartment remain poorly understood. Dissociated
cultures of cerebellar granule cells (GCs) demonstrate improved long-term survival when
their growth medium is supplemented with depolarizing agents that stimulate Ca 2+ influx
and activate calmodulin-dependent signaling cascades, notably 20 mm KCl. We previously
observed Ca 2+-dependent down-regulation of Ca 2+/calmodulin-dependent protein kinase …
nucleus, but their functions in this compartment remain poorly understood. Dissociated
cultures of cerebellar granule cells (GCs) demonstrate improved long-term survival when
their growth medium is supplemented with depolarizing agents that stimulate Ca 2+ influx
and activate calmodulin-dependent signaling cascades, notably 20 mm KCl. We previously
observed Ca 2+-dependent down-regulation of Ca 2+/calmodulin-dependent protein kinase …