Impaired T-cell receptor activation in IL-1 receptor–associated kinase-4–deficient patients
DR McDonald, F Goldman, OD Gomez-Duarte… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: IL-1 receptor–associated kinase 4 (IRAK-4) is an effector of the Toll-like
receptor and IL-1 receptor pathways that plays a critical role in innate immune responses.
The role of IRAK-4 in adaptive immune functions in human subjects is incompletely
understood. OBJECTIVE: We sought to evaluate T-cell function in IRAK-4 deficient patients.
METHODS: We compared upregulation of CD25 and CD69 on T cells and production of IL-
2, IL-6, and IFN-γ after stimulation of PBMCs from 4 IRAK-4–deficient patients and healthy …
receptor and IL-1 receptor pathways that plays a critical role in innate immune responses.
The role of IRAK-4 in adaptive immune functions in human subjects is incompletely
understood. OBJECTIVE: We sought to evaluate T-cell function in IRAK-4 deficient patients.
METHODS: We compared upregulation of CD25 and CD69 on T cells and production of IL-
2, IL-6, and IFN-γ after stimulation of PBMCs from 4 IRAK-4–deficient patients and healthy …