Addressing diffuse glioma as a systemic brain disease with single-cell analysis
F Sahm, D Capper, A Jeibmann, A Habel… - Archives of …, 2012 - jamanetwork.com
Objective To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by
identification of single tumor cells applying an antibody specific to mutant IDH1 R132H
protein. Design Immunohistochemical analysis. Setting University hospital. Patients Whole-
brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. Results Tumor
cells were identified in areas that appeared inconspicuous macroscopically and at
histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all …
identification of single tumor cells applying an antibody specific to mutant IDH1 R132H
protein. Design Immunohistochemical analysis. Setting University hospital. Patients Whole-
brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. Results Tumor
cells were identified in areas that appeared inconspicuous macroscopically and at
histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all …