ERBBs in the gastrointestinal tract: recent progress and new perspectives
WH Fiske, D Threadgill, RJ Coffey - Experimental cell research, 2009 - Elsevier
WH Fiske, D Threadgill, RJ Coffey
Experimental cell research, 2009•ElsevierThe gastrointestinal epithelium does much more than provide a physical barrier between the
intestinal lumen and our internal milieu. It is actively engaged in absorption and secretion of
salt and water via ion transporters, exchangers and selective ion channels. It is also a
continuously self-renewing epithelium that undergoes ordered growth and differentiation
along its vertical axis. From this dual perspective, we will consider the actions of the ERBB
family of ligands and receptors in the maintenance of gastrointestinal homeostasis and …
intestinal lumen and our internal milieu. It is actively engaged in absorption and secretion of
salt and water via ion transporters, exchangers and selective ion channels. It is also a
continuously self-renewing epithelium that undergoes ordered growth and differentiation
along its vertical axis. From this dual perspective, we will consider the actions of the ERBB
family of ligands and receptors in the maintenance of gastrointestinal homeostasis and …
The gastrointestinal epithelium does much more than provide a physical barrier between the intestinal lumen and our internal milieu. It is actively engaged in absorption and secretion of salt and water via ion transporters, exchangers and selective ion channels. It is also a continuously self-renewing epithelium that undergoes ordered growth and differentiation along its vertical axis. From this dual perspective, we will consider the actions of the ERBB family of ligands and receptors in the maintenance of gastrointestinal homeostasis and discuss instances when the actions of this family go awry such as in cancer and Ménétrier's disease.
Elsevier
