[HTML][HTML] TRPC1 protein channel is major regulator of epidermal growth factor receptor signaling
N Tajeddine, P Gailly - Journal of Biological Chemistry, 2012 - ASBMB
TRP channels have been associated with cell proliferation and aggressiveness in several
cancers. In particular, TRPC1 regulates cell proliferation and motility, two processes
underlying cancer progression. We and others have described the mechanisms of TRPC1-
dependent cell migration. However, the involvement of TRPC1 in cell proliferation remains
unexplained. In this study, we show that siRNA-mediated TRPC1 depletion in non small cell
lung carcinoma cell lines induced G 0/G 1 cell cycle arrest resulting in dramatic decrease in …
cancers. In particular, TRPC1 regulates cell proliferation and motility, two processes
underlying cancer progression. We and others have described the mechanisms of TRPC1-
dependent cell migration. However, the involvement of TRPC1 in cell proliferation remains
unexplained. In this study, we show that siRNA-mediated TRPC1 depletion in non small cell
lung carcinoma cell lines induced G 0/G 1 cell cycle arrest resulting in dramatic decrease in …
