Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas
H Colman, C Giannini, LI Huang… - The American journal …, 2006 - journals.lww.com
Distinguishing between grade II and grade III diffuse astrocytomas is important both for
prognosis and for treatment decision-making. However, current methods for distinguishing
between grades based on proliferative potential are suboptimal, making identification of
clear cutoffs difficult. In this study, we compared the results from immunohistochemical
staining for phospho-histone H3 (pHH3), a specific marker of cells undergoing mitosis, with
standard mitotic counts (number of mitoses/10 high-power fields) and MIB-1 labeling index …
prognosis and for treatment decision-making. However, current methods for distinguishing
between grades based on proliferative potential are suboptimal, making identification of
clear cutoffs difficult. In this study, we compared the results from immunohistochemical
staining for phospho-histone H3 (pHH3), a specific marker of cells undergoing mitosis, with
standard mitotic counts (number of mitoses/10 high-power fields) and MIB-1 labeling index …