[HTML][HTML] Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B–/–mice
Protein-tyrosine phosphatase 1B (PTP1B) is an important negative regulator of insulin and
leptin signaling in vivo. Mice lacking PTP1B (PTP1B–/–mice) are hyper-responsive to insulin
and leptin and resistant to diet-induced obesity. The tissue (s) that mediate these effects of
global PTP1B deficiency remain controversial. We exploited the high degree of
hepatotropism of adenoviruses to assess the role of PTP1B in the liver. Liver-specific re-
expression of PTP1B in PTP1B–/–mice led to marked attenuation of their enhanced insulin …
leptin signaling in vivo. Mice lacking PTP1B (PTP1B–/–mice) are hyper-responsive to insulin
and leptin and resistant to diet-induced obesity. The tissue (s) that mediate these effects of
global PTP1B deficiency remain controversial. We exploited the high degree of
hepatotropism of adenoviruses to assess the role of PTP1B in the liver. Liver-specific re-
expression of PTP1B in PTP1B–/–mice led to marked attenuation of their enhanced insulin …