The most common cause of kidney transplant failure is the poorly characterized
histopathologic entity interstitial fibrosis and tubular atrophy (IFTA). There are no known
unifying mechanisms, no effective therapy, and no proven preventive strategies. Possible
mechanisms include chronic immune rejection, inflammation, drug toxicity, and chronic
kidney injury from secondary factors. To gain further mechanistic insight, we conducted a
large-scale proteogenomic study of kidney transplant biopsies with IFTA of varying severity …