The DNA demethylating agent 5-aza-2′-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells
M Almstedt, N Blagitko-Dorfs, J Duque-Afonso… - Leukemia research, 2010 - Elsevier
Azanucleoside DNA-hypomethylating agents have remarkable clinical activity in
myelodysplastic syndromes and acute myeloid leukemia (AML), particularly at low, non-
cytotoxic doses favoring hypomethylation over cytotoxicity. Cancer/testis antigens (CTAs)
encoding immunogenic proteins are not expressed in almost all normal tissues and many
tumor types, but are consistently derepressed by epigenetically active agents in various
cancer cell lines. Since the expression of CTA genes is usually very low or absent in myeloid …
myelodysplastic syndromes and acute myeloid leukemia (AML), particularly at low, non-
cytotoxic doses favoring hypomethylation over cytotoxicity. Cancer/testis antigens (CTAs)
encoding immunogenic proteins are not expressed in almost all normal tissues and many
tumor types, but are consistently derepressed by epigenetically active agents in various
cancer cell lines. Since the expression of CTA genes is usually very low or absent in myeloid …
